Haematologic Technologies所有產(chǎn)品目錄
Haematologic Technologies
代理公司介紹：haemtech
域名名字里 單詞拆分 haem（血紅素）tech（科技），
Haematologic （血液學(xué)），也就說這家公司的產(chǎn)品都是人體血液相關(guān)蛋白以及抗體
Haematologic Technologies公司是一家專門致力于高質(zhì)量的人血漿蛋白的分離和特性研究、生產(chǎn)及高通量上等抗體的行業(yè)***，公司產(chǎn)品主要用于體外研究。該公司核心產(chǎn)品包括凝血級聯(lián)反應(yīng)以及骨代謝調(diào)控相關(guān)蛋白，全部產(chǎn)品線包括150多種高純度、高性能的蛋白產(chǎn)品，具體有酶原、酶、協(xié)同因子、底物和抑制劑、樣品收集管及抗凝管等。除高純蛋白產(chǎn)品外，Haematologic Technologies是世界上*大的單克隆抗體和蛋白生產(chǎn)商之一，通過利用染色體組/蛋白質(zhì)組的方法開發(fā)抗體，公司可提供上萬種單/多克隆抗體，力求針對每一個人類表達基因開發(fā)至少一種抗體產(chǎn)品。此外，公司還提供部分技術(shù)服務(wù)，如：蛋白定制、純化、修飾檢測、定制生產(chǎn)與科研合作等。
公司使命：為全球凝血研究領(lǐng)域提供高品質(zhì)的高純高活性蛋白及相關(guān)試劑，同時持續(xù)改進我們的蛋白生產(chǎn)和質(zhì)控標準，以及通過挖掘內(nèi)部潛力及與血栓/止血研究領(lǐng)域的**研究機構(gòu)和企業(yè)進行戰(zhàn)略合作以確保公司前沿領(lǐng)軍地位。
公司核心競爭力：Haematologic Technologies通過以下三方面優(yōu)勢從眾多競爭者中脫穎而出：上等的技術(shù)服務(wù)、智力資源、定制生產(chǎn)與研究。上等的技術(shù)服務(wù)部是公司的*大優(yōu)勢，可為使用本公司產(chǎn)品的客戶提供****的服務(wù)，為客戶提供完善的實驗設(shè)計、實驗方法及常見問題等方面的詳盡建議，使使用產(chǎn)品的科學(xué)家無形中參與公司產(chǎn)品的生產(chǎn)和研發(fā)。
公司主要產(chǎn)品系列：
一、人血漿產(chǎn)品系列：
該產(chǎn)品系列包括凝血因子及抑制劑、血小板和骨代謝調(diào)控相關(guān)蛋白質(zhì)。
1、酶原：包括：Factor VII、Factor IX、Factor X、Factor X (修飾)、Factor XI、Factor XII、Factor XIII、glu-Plasminogen、lys-Plasminogen、Protein C、Prothrombin。
2、酶類：包括：、Activated Protein C*、Thrombin (alpha)*、Thrombin (beta, gamma)、Factor VIIa、Factor IXa*、Factor Xa* (gla-domainless available)、Factor XIa、Factor XIIIa、Plasmin、(*可提供封閉活性位點產(chǎn)品)。
3、輔酶因子：包括：Factor V、Factor Va、Fibronectin、Protein S、von Willebrand Factor（vWF）、von Willebrand Factor (無VIII 因子)、Thrombomodulin (兔)、Protein Z。
4、蛋白酶抑制劑：包括：Antithrombin III、Heparin Cofactor II、TAFI、Angiostatin、Alpha-2-Plasmin Inhibitor。
5、蛇毒蛋白酶：包括：RVV-X Activator、RVV-V Activator、E. Carinatus II Protease
6、人血小板和其它血漿蛋白產(chǎn)品：包括：Fibrinogen & Fragments、Beta-2-Glycoprotein-1、Human Platelet Osteonectin、Platelet Factor 4、Beta-Thromboglobulin、Thrombospondin、Vitronectin、Recombinant Tissue Factor
7、骨相關(guān)蛋白酶：Osteocalcin
二、牛血漿產(chǎn)品系列：
該產(chǎn)品系列包括凝血因子及抑制劑、血小板和骨代謝調(diào)控相關(guān)蛋白質(zhì)。
1、酶原：包括：Bovine Factor IX、Bovine Factor X、Bovine Plasminogen、Bovine Protein C、Bovine Prothrombin。
2、酶類：包括：Bovine Activated Protein C、Bovine Thrombin、Bovine Factor IXa、Bovine Factor Xa，均可提供封閉活性位點產(chǎn)品。
3、輔酶因子：包括：Bovine Factor V、Bovine Factor Va。
4、骨代謝相關(guān)蛋白：Osteocalcin。
5、蛇毒蛋白酶：包括RVV-X Activator、RVV-V Activator及E. Carinatus II Protease。
6、新產(chǎn)品：Bovine Lactadherin
三、小鼠血漿產(chǎn)品系列：
1、酶原：包括：Mouse Factor X、Mouse Plasminogen、Mouse Prothrombin、Mouse Prothrombin Frag-1 (please call)、Mouse Prethrombin-2 (please call)。
2、酶類：包括：Mouse Thrombin、Mouse Factor Xa、Mouse Plasmin。
3、部分血液蛋白相關(guān)抗體：
（1）單克隆抗體：包括：Rat anti-Mouse Protein C、Rat anti-Mouse Prothrombin Rat anti-Mouse Plasminogen、Rat anti-Mouse Factor X、Rat anti-Mouse Factor VIII。
（2）多克隆抗體：包括：Sheep anti-Mouse Factor X、Sheep anti-Mouse Factor X - Immuno Adsorbed、Sheep anti-Mouse Prothrombin、Sheep anti-Mouse Plasminogen、Sheep anti-Mouse Protein C、Sheep anti-Mouse ATIII、Sheep anti-Mouse Fibrinogen、Sheep anti-Rat Factor IX。
4、其它產(chǎn)品：Mouse Antithrombin III、Mouse Fibrinogen、Rat Factor IX (please call)、Rat Factor IXa (please call)、Rat Factor X (please call)、Rat Thrombin (please call)、Rat Prethrombin-2 (please call)、Rat Fibrinogen (please call)、Rabbit Thrombomodulin。
四、抑制劑產(chǎn)品系列：
1、氯基甲酮產(chǎn)品：包括：FPR-chloromethylketone (PPACK)、EGR-chloromethylketone (GGACK)、Biotinylated EGR-chloromethylketone、Fluorescein EGR-chloromethylketone、Biotinylated FPR-chloromethylketone、Fluorescein FPR-chloromethylketone。
2、人蛋白酶抑制劑：Antithrombin III、Heparin Cofactor II、TAFI、Angiostatin、Alpha-2-Plasmin Inhibitor。
3、其它產(chǎn)品：包括玉米胰蛋白酶抑制劑(CTI)和DAPA。
品牌鏈接：http://www.hbhuard.cn/goodsid/ziliaoview/271640.html
Haematologic Technologies,Haematologic Technologies代理,Haematologic Technologies銷售,Haematologic Technologies公司,Haematologic Technologies產(chǎn)品,Haematologic Technologies價格
部分列表
| HCVII-0030 | Human Factor VII | | Haematologic Technologies |
| ABOC-5021 | Anti-Bovine Osteocalcin | | Haematologic Technologies |
| ABV-5103 | Anti-Bovine Factor V | | Haematologic Technologies |
| ABV-5104 | Anti-Bovine Factor V | | Haematologic Technologies |
| ABV-5105 | Anti-Bovine Factor V | | Haematologic Technologies |
| ABV-5106 | Anti-Bovine Factor V | | Haematologic Technologies |
| ABV-5107 | Anti-Bovine Factor V | | Haematologic Technologies |
| ABX-5051 | Anti-Bovine Factor X | | Haematologic Technologies |
| AHIX-5041 | Anti-Human Factor IX | | Haematologic Technologies |
| AHP-5013 | Anti-Human Prothrombin | | Haematologic Technologies |
| AHPC-5011 | Anti-Human Protein C | | Haematologic Technologies |
| AHPC-5071 | Anti-Human Protein C | | Haematologic Technologies |
| AHPC-5072 | Anti-Human Protein C | | Haematologic Technologies |
| AHPS-5091 | Anti-Human Protein S | | Haematologic Technologies |
| AHPS-5092 | Anti-Human Protein S | | Haematologic Technologies |
| AHT-5020 | Anti-Human Thrombin | | Haematologic Technologies |
| AHTF-5264 | Anti-Human Tissue Factor | | Haematologic Technologies |
| AHTFPI-5138 | Anti-Human Tissue Factor Pathway Inhibitor | | Haematologic Technologies |
| AHV-5101 | Anti-Human Factor V | | Haematologic Technologies |
| AHV-5102 | Anti-Human Factor V | | Haematologic Technologies |
| AHV-5108 | Anti-Human Factor V | | Haematologic Technologies |
| AHV-5110 | Anti-Human Factor V | | Haematologic Technologies |
| AHV-5112 | Anti-Human Factor V | | Haematologic Technologies |
| AHV-5146 | Anti-Human Factor V | | Haematologic Technologies |
| AHVII-5031 | Anti-Human Factor VII | | Haematologic Technologies |
| AHVIII-5025 | Anti-Human Factor VIII | | Haematologic Technologies |
| AHX-5050 | Anti-Human Factor X | | Haematologic Technologies |
| AHXI-5061 | Anti-Human Factor XI | | Haematologic Technologies |
| AHXII-5155 | Anti-Human Factor XII | | Haematologic Technologies |
| AMP-9013 | Rat anti-Mouse Prothrombin | | Haematologic Technologies |
| AMPC-9071 | Rat anti-Mouse Protein C | | Haematologic Technologies |
| AMPC-9072 | Rat anti-Mouse Protein C | | Haematologic Technologies |
| AMPG-9130 | Rat anti-Mouse Plasminogen | | Haematologic Technologies |
| AMVII-9031 | Anti-Mouse Factor VII | | Haematologic Technologies |
| AMVIII-9035 | Anti-Mouse Factor VIII | | Haematologic Technologies |
| AMX-9050 | Rat Anti-Mouse Factor X | | Haematologic Technologies |
| AMX-9051 | Rat Anti-Mouse Factor X | | Haematologic Technologies |
| ANG-01 | Angiostatin | | Haematologic Technologies |
| AON-5031 | Anti-Human Osteonectin | | Haematologic Technologies |
| B2GI-0001 | β2 Glycoprotein I | | Haematologic Technologies |
| BCAPC-1080 | Bovine APC | | Haematologic Technologies |
| BCAPC-DEGR | Bovine APC-DEGR | | Haematologic Technologies |
| BCIX-1040 | Bovine Factor IX | | Haematologic Technologies |
| BCIXA-1050 | Bovine Factor IXa | | Haematologic Technologies |
| BCIXA-DEGR | Bovine Factor IXa-DEGR | | Haematologic Technologies |
| BCIXA-EGR | Bovine Factor IXa-EGR | | Haematologic Technologies |
| BCP-1010 | Bovine Prothrombin | | Haematologic Technologies |
| BCPC-1070 | Bovine Protein C | | Haematologic Technologies |
| BCPG-1130 | Bovine Plasminogen | | Haematologic Technologies |
| BCT-1020 | Bovine α-thrombin | | Haematologic Technologies |
| BCT-BFPRCK | Bovine α-thrombin-BFPRCK | | Haematologic Technologies |
| BCT-DFP | Bovine α-thrombin-DFP | | Haematologic Technologies |
| BCT-FPRCK | Bovine α-thrombin-FPRCK | | Haematologic Technologies |
| BCV-1100 | Bovine Factor V | | Haematologic Technologies |
| BCVA-1110 | Bovine Factor Va | | Haematologic Technologies |
| BCX-1050 | Bovine Factor X | | Haematologic Technologies |
| BCXA-1060 | Bovine Factor Xa | | Haematologic Technologies |
| BCXA-DEGR | Bovine Factor Xa-DEGR | | Haematologic Technologies |
| BCXA-EGR | Bovine Factor Xa-EGR | | Haematologic Technologies |
| BEGRCK-06 | Biotinylated EGR-chloromethylketone | | Haematologic Technologies |
| BFPRCK-06 | Biotinylated FPR-chloromethylketone | | Haematologic Technologies |
| BLAC-1200 | Bovine Lactadherin | | Haematologic Technologies |
| BLAC-FITC | FITC-conjugated Bovine Lactadherin (1.6 uM) | | Haematologic Technologies |
| BOC-3020 | Bovine Osteocalcin | | Haematologic Technologies |
| BON-3010 | Bovine Osteonectin | | Haematologic Technologies |
| CTI-01 | Corn Trypsin Inhibitor | | Haematologic Technologies |
| DAPA | dansylarginine-N- | | Haematologic Technologies |
| ECVVII-2011 | E. Carinatus II Protease | | Haematologic Technologies |
| EGRCK-01 | Glu-Gly-Arg-chloromethylketone | | Haematologic Technologies |
| FEGRCK-06 | Fluorescein EGR-chloromethylketone | | Haematologic Technologies |
| FFPRCK-06 | Fluorescein FPR-chloromethylketone | | Haematologic Technologies |
| FPRCK-01 | Phe-Pro-Arg-chloromethylketone | | Haematologic Technologies |
| HA2AP-0230 | Human α-2 Plasmin Inhibitor | | Haematologic Technologies |
| HBTG-0210 | Human β-Thromboglobulin | | Haematologic Technologies |
| HCAPC-0080 | Human APC | | Haematologic Technologies |
| HCAPC-DEGR | Human APC-DEGR | | Haematologic Technologies |
| HCATIII-0120 | Human Antithrombin III | | Haematologic Technologies |
| HCBT-0022 | Human b-thrombin | | Haematologic Technologies |
| HCBXA-0061 | Human β-Factor Xa | | Haematologic Technologies |
| HCFN-0170 | Human Fibronectin | | Haematologic Technologies |
| HCGT-0021 | Human g-thrombin | | Haematologic Technologies |
| HCI-0150D | Human Fibrinogen Fragment D | | Haematologic Technologies |
| HCI-0150E | Human Fibrinogen Fragment E | | Haematologic Technologies |
| HCI-0150R | Human Fibrinogen | | Haematologic Technologies |
| HCII-0190 | Human Heparin Cofactor II | | Haematologic Technologies |
| HCIX-0040 | Human Factor IX | | Haematologic Technologies |
| HCIXA-0050 | Human Factor IXa | | Haematologic Technologies |
| HCIXA-DEGR | Human Factor IXa-DEGR | | Haematologic Technologies |
| HCIXA-EGR | Human Factor IXa-EGR | | Haematologic Technologies |
| HCP-0010 | Human Prothrombin | | Haematologic Technologies |
| HCP1-0010 | Human Prothrombin Fragment 1 | | Haematologic Technologies |
| HCP1-0011 | Human Prethrombin-1 | | Haematologic Technologies |
| HCP12-0010 | Human Prothrombin Fragment 1 - 2 | | Haematologic Technologies |
| HCP2-0010 | Human Prothrombin Fragment 2 | | Haematologic Technologies |
| HCP2-0011 | Human Prethrombin-2 | | Haematologic Technologies |
| HCPC-0070 | Human Protein C | | Haematologic Technologies |
| HCPG-0130 | Human glu-Plasminogen | | Haematologic Technologies |
| HCPG-0131 | Human glu-Plasminogen (affinity form I) | | Haematologic Technologies |
| HCPG-0132 | Human glu-Plasminogen (affinity form II) | | Haematologic Technologies |
| HCPG-0133 | Human lys-Plasminogen | | Haematologic Technologies |
| HCPM-0140 | Human Plasmin | | Haematologic Technologies |
| HCPS-0090 | Human Protein S | | Haematologic Technologies |
| HCPZ-0220 | Human Protein Z | | Haematologic Technologies |
| HCT-0020 | Human α-thrombin | | Haematologic Technologies |
| HCT-BFPRCK | Human α-thrombin-BFPRCK | | Haematologic Technologies |
| HCT-DFP | Human α-thrombin-DFP | | Haematologic Technologies |
| HCT-FPRCK | Human α-thrombin-FPRCK | | Haematologic Technologies |
| HCTP-0200 | Human Thrombospondin | | Haematologic Technologies |
| HCV-0100 | Human Factor V | | Haematologic Technologies |
| HCVA-0110 | Human Factor Va | | Haematologic Technologies |
| HCVIIA-0031 | Human Factor VIIa | | Haematologic Technologies |
| HCVWF-0190 | Human von Willebrand Factor | | Haematologic Technologies |
| HCVWF-0191 | Human von Willebrand Factor (Factor VIII free) | | Haematologic Technologies |
| HCX-0050 | Human Factor X | | Haematologic Technologies |
| HCXA-0060 | Human Factor Xa | | Haematologic Technologies |
| HCXA-BEGR | Human Factor Xa-BEGR | | Haematologic Technologies |
| HCXA-DEGR | Human Factor Xa-DEGR | | Haematologic Technologies |
| HCXA-EGR | Human Factor Xa-EGR | | Haematologic Technologies |
| HCXA-GD | Human Gla-Domainless β-Factor Xa | | Haematologic Technologies |
| HCX-GD | Human Gla-domainless Factor X | | Haematologic Technologies |
| HCXI-0150 | Human Factor XI | | Haematologic Technologies |
| HCXIA-0160 | Human Factor XIa | | Haematologic Technologies |
| HCXII-0155 | Human Factor XII | | Haematologic Technologies |
| HCXIII-0160 | Human Factor XIII | | Haematologic Technologies |
| HCXIIIA-0165 | Human Factor XIIIa | | Haematologic Technologies |
| HOC-0302 | Human Osteocalcin | | Haematologic Technologies |
| HON-0303 | Human Osteonectin | | Haematologic Technologies |
| HPF4-0180 | Human Platelet Factor 4 | | Haematologic Technologies |
| HVN-0230 | Human Vitronectin | | Haematologic Technologies |
| MCAPC-5080 | Mouse APC | | Haematologic Technologies |
| MCATIII-5120 | Mouse Antithrombin III | | Haematologic Technologies |
| MCI-5150 | Mouse Fibrinogen | | Haematologic Technologies |
| MCIX-5040 | Mouse Factor IX | | Haematologic Technologies |
| MCIXA-5050 | Mouse Factor IXa | | Haematologic Technologies |
| MCP-5010 | Mouse Prothrombin | | Haematologic Technologies |
| MCPC-5070 | Mouse Protein C | | Haematologic Technologies |
| MCPG-5130 | Mouse Plasminogen | | Haematologic Technologies |
| MCPM-5140 | Mouse Plasmin | | Haematologic Technologies |
| MCT-5020 | Mouse Thrombin | | Haematologic Technologies |
| MCX-5050 | Mouse Factor X | | Haematologic Technologies |
| MCXA-5060 | Mouse Factor Xa | | Haematologic Technologies |
| PABFV-S | Sheep anti-Human Factor V | | Haematologic Technologies |
| PAHAT-S | Sheep anti-Human Antithrombin III | | Haematologic Technologies |
| PAHCII-S | Sheep anti-Heparin Cofactor II | | Haematologic Technologies |
| PAHF4-RAB | Rabbit anti-Human Platelet Factor 4 | | Haematologic Technologies |
| PAHFII-BU | Burro anti-Human Prothrombin | | Haematologic Technologies |
| PAHFII-S | Sheep anti-Human Prothrombin | | Haematologic Technologies |
| PAHFII-SAP | Sheep anti-Human Prothrombin, Affinity Purified | | Haematologic Technologies |
| PAHFIX-C | Chicken anti-Human Factor IX | | Haematologic Technologies |
| PAHFIX-S | Sheep anti-Human Factor IX | | Haematologic Technologies |
| PAHFIX-SAP | Sheep anti-Human Factor IX, Affinity Purified | | Haematologic Technologies |
| PAHFVA-S | Sheep anti-Human Factor Va | | Haematologic Technologies |
| PAHFV-H | Horse anti-Human Factor V | | Haematologic Technologies |
| PAHFVIIA-RAB | Rabbit anti-Human Factor VIIa | | Haematologic Technologies |
| PAHFVIII-S | Sheep anti-Human Factor VIII | | Haematologic Technologies |
| PAHFVII-S | Sheep anti-Human Factor VII | | Haematologic Technologies |
| PAHFV-S | Sheep anti-Human Factor V | | Haematologic Technologies |
| PAHFXIII-S | Sheep anti-Human Factor XIII | | Haematologic Technologies |
| PAHFXII-S | Sheep anti-Human Factor XII | | Haematologic Technologies |
| PAHFXI-S | Sheep anti-Human Factor XI | | Haematologic Technologies |
| PAHFXI-SAP | Sheep anti-Human Factor XI, Affinity Purified | | Haematologic Technologies |
| PAHFX-S | Sheep anti-Human Factor X | | Haematologic Technologies |
| PAHPC-C | Chicken anti-Human Protein C | | Haematologic Technologies |
| PAHPC-H | Horse anti-Human Protein C | | Haematologic Technologies |
| PAHPC-S | Sheep anti-Human Protein C | | Haematologic Technologies |
| PAHPG-S | Sheep anti-Human Plasminogen | | Haematologic Technologies |
| PAHPS-S | Sheep anti-Human Protein S | | Haematologic Technologies |
| PAHPZ-S | Sheep anti-Human Protein Z | | Haematologic Technologies |
| PAHTFPI-S | Sheep anti-Human Tissue Factor Pathway Inhibitor | | Haematologic Technologies |
| PAHTF-S | Sheep anti-Human Tissue Factor | | Haematologic Technologies |
| PAHT-S | Sheep anti-Human Thrombin | | Haematologic Technologies |
| PAHVWF-S | Sheep anti-Human vWF | | Haematologic Technologies |
| PAMFII-S | Sheep anti-Mouse Prothrombin | | Haematologic Technologies |
| PAMFX-S | Sheep anti-Murine Factor X | | Haematologic Technologies |
| PAMFX-SIA | Sheep anti-Murine Factor X - Immuno adsorbed | | Haematologic Technologies |
| PAMPC-S | Sheep anti-Murine Protein C | | Haematologic Technologies |
| PAMPG-S | Sheep anti-Mouse Plasminogen | | Haematologic Technologies |
| PAPFGN-S | Sheep anti-Porcine Fibrinogen | | Haematologic Technologies |
| PATAFI-S | Sheep anti-Human TAFI | | Haematologic Technologies |
| RABTM-4202 | Rabbit Thrombomodulin | | Haematologic Technologies |
| RTF-0300 | Recombinant Tissue Factor | | Haematologic Technologies |
| RVVV-2000 | RVV-V Activator | | Haematologic Technologies |
| RVVX-2010 | RVV-X Activator | | Haematologic Technologies |
| SCAT-27-4.5/5 | CTI/Citrate Blood Collection Tube | | Haematologic Technologies |
| TAFI-01 | Thrombin-Activatable Fibrinolysis Inhibitor | | Haematologic Technologies |
Haematologic Technologies 中國代理, Haematologic Technologies 上海代理， Haematologic Technologies 北京代理，Haematologic Technologies 廣東代理， Haematologic Technologies 江蘇代理Haematologic Technologies 湖北代理,Haematologic Technologies 天津,Haematologic Technologies黑龍江代理,Haematologic Technologies 內(nèi)蒙古代理,Haematologic Technologies 吉林代理,Haematologic Technologies 福建代理, Haematologic Technologies 江蘇代理, Haematologic Technologies 浙江代理,Haematologic Technologies 四川代理,
Haematologic Technologies Inc. (HTI) 公司是一家專門致力于高質(zhì)量的人血漿蛋白的分離和特性研究的重要生產(chǎn)商， 其產(chǎn)品非常適用于體內(nèi)研究。在公司發(fā)展的**個十年里，HTI將目光投向參與血液凝集和纖維蛋白溶解，以及骨代謝調(diào)節(jié)的蛋白的研究。HTI產(chǎn)品系列含有* 過100種高純度和特異性的蛋白，包括：酶原、酶、協(xié)同因子和抑制劑，同時還提供補體系列的單克隆和多克隆抗體。另外，HTI還提供一些技術(shù)服務(wù)，如：蛋 白定制、純化、修飾、科研合作等。
Human Coagulation Factor XIIIa
人凝血因子XIIIa
纖維蛋白
的穩(wěn)定可溶性纖維蛋白轉(zhuǎn)化為不溶性纖維蛋白凝塊由轉(zhuǎn)座酰胺酶XIIIa催化。纖維蛋白的α-和γ-鏈的賴氨酸和谷氨酰胺側(cè)鏈交聯(lián)以形成均聚物。
HCXIIIA-0165 人體因子XIIIa
尺寸 50μg
公式 50％甘油/ 500uM EDTA（v / v）
存儲 -20℃下
純度 > 95％通過SDS-PAGE
活動確定 光度測定
保質(zhì)期（妥善儲存） 12個月
樣品凝膠信息：
凝膠 Novex 4-12％Bis-Tris
加載 人因子XIIIa，每泳道1μg
緩沖 MOPS
標準 SeeBluePlus 2; 肌球蛋白（191kDa），磷酸化酶B（97kDa），BSA（64kDa），谷氨酸脫氫酶（51kDa），醇脫氫酶（39kDa），碳酸酐酶（28kDa），肌紅蛋白紅（19kDa），溶菌酶kDa的）
特別說明 在未還原的樣品中，A鏈在活化后朝向B鏈向下移動。
概述
因子XIIIa（FXIIIa）（纖維蛋白溶血素，血漿轉(zhuǎn)谷氨酰胺酶，纖維蛋白穩(wěn)定因子，EC 2.3.2.13）是在凝血級聯(lián)的*后階段起作用的谷氨酰胺?；?谷氨酰轉(zhuǎn)移酶，通過交聯(lián)α和γ鏈穩(wěn)定纖維蛋白凝塊的纖維蛋白以形成均聚物（1-4）。FXIIIa的幾個獨特功能使其與通常與之相關(guān)的蛋白質(zhì)分開。因子XIIIa是凝血級聯(lián)的**非蛋白水解酶。與其他轉(zhuǎn)座酰胺酶不同，它完全以酶原形式存在，是**在細胞外起作用的巰基酶。
血漿FXIIIa是由2對不相同亞基（A2B2）（4-7）組成的四聚體（Mr = 312,000）。血小板FXIII是二聚體（Mr = 46,000），僅由一對相同的A亞基（A2）組成，如來自所有細胞內(nèi)源的因子XIII（7-11）。A亞基含有6個游離的巰基，其中之一是活性中心（12）。
血漿FXIII（A2B2）轉(zhuǎn)化為活性轉(zhuǎn)谷氨酰胺酶FXIIIa（A2'）是由A亞基（13）的NH2-末端的Arg36-Gly37肽鍵的凝血酶催化水解產(chǎn)生的。由該切割誘導(dǎo)的構(gòu)象變化導(dǎo)致活性位點半胱氨酸的暴露。完全活性僅在B亞基二聚體從A2'二聚體（14-16）的Ca2 +依賴性（Kd = 10-3M）解離之后才實現(xiàn)。通過結(jié)合含有Aa鏈殘基242-424（14-16）的纖維蛋白（ogen）區(qū)域，可增強A2'B2復(fù)合物的解離。因此，在FXIII（90nM），纖維蛋白原（8μM）和Ca 2+（2.5mM游離）的正常血漿濃度下，產(chǎn)生的所有FXIIIa將處于完全活化（A2'）分子形式。由FXIIIa產(chǎn)生的其他與生理相關(guān)的交聯(lián)復(fù)合物包括纖維蛋白纖維蛋白原（17），纖維蛋白 - 纖連蛋白（18），纖維蛋白-vWF（19），纖維蛋白-α2-抗血纖蛋白（20），纖維蛋白 - 肌動蛋白（21），纖維蛋白 - 血小板反應(yīng)蛋白纖連蛋白膠原（19），vWF膠原（19），肌動蛋白肌球蛋白（21,22），因子V因子V（23）。除了凝塊穩(wěn)定之外，F(xiàn)XIIIa被認為在涉及細胞增殖的各種過程中起作用，例如傷口**，組織重塑，動脈粥樣硬化和腫瘤生長。
血漿FXIIIa通過α-淀粉酶在EDTA存在下裂解均質(zhì)血漿FXIII產(chǎn)生。通過離子和親和層析純化A2'B2亞基，并在50％甘油0.5mM EDTA中提供，以在-20℃下儲存。
Overview
Haematologic Technologies, Inc. (HTI), an ISO 9001:2015 registered company, is a primary manufacturer that specializes in the isolation and characterization of high quality, plasma proteins which are intended for in vitro research use. HTI’s emphasis is focused on proteins involved in the coagulation cascade, as well as the regulation of bone metabolism. The HTI product line consists of over 150 highly purified and well-characterized proteins including zymogens, enzymes, cofactors, and inhibitors as well as a complementary line of monoclonal and polyclonal antibodies. Also available are factor deficient plasmas and customized, blood collection tubes made-to-order for clinical research. Services available include custom protein purification, protein modification, assay development, contract manufacturing and contract research. Please view our 3-minute video above.
Mission
The mission of Haematologic Technologies, Inc. is to supply the international coagulation research community with the highest quality proteins and reagents attainable. We strive to make continuous advancements in our manufacturing and quality control processes to ensure the superiority of our products to those of our competitors. HTI also endeavors to be on the cutting edge of coagulation research through in-house efforts and the formation of strategic relationships with firms at the top of thrombosis and hemostasis research.
Differentiation
Haematologic Technologies differentiates itself from its competitors by three main factors: excellent technical service, intellectual resources and custom manufacturing and research. HTI’s marquee difference is its technical service department, which strives to give customers unparalleled service for our products and their uses. When customers and distributors call with technical concerns, they can speak to a Ph.D. scientist that is actually involved with the manufacture of the product. Often, our technical service personnel go above and beyond the expected to provide customers with recommendations for their experimental problems, experimental design and procedural assistance. HTI feels that this type of relationship with its customers is the key to our success, and we will always provide this level of service to any of our customers. What’s more, HTI’s consultants are always at hand to provide an extra level of assistance if needed.
Quality Policy
"HTI is committed to achieving the highest level of customer satisfaction, and to the continual improvement of its products, services and quality management system." For a copy of our ISO certificate please click here.
Coagulation Products
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Human Proteins
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Human Zymogens
Factor VII
Factor IX
Factor X
Factor XI
Factor XII
Factor XIII
Plasminogen
Protein C
Prothrombin
Human Enzymes
Activated Protein C
Thrombin (alpha)
Thrombin (beta, gamma)
Factor VIIa
Factor IXa
Factor Xa
Factor XIa
Factor XIIIa
Plasmin
Human Cofactors
Factor V
Factor Va
Fibronectin
Protein S
von Willebrand Factor
Protein Z
Human Protease Inhibitors
Human Antithrombin III
Heparin Cofactor II
TAFI
Angiostatin
Alpha-2-Plasmin Inhibitor
Human Platelet & Other Plasma Proteins
Fibrinogen
Beta-2-Glycoprotein 1
Platelet Factor 4
Beta-Thromboglobulin
Thrombospondin
Vitronectin
Recombinant Tissue Factor
Human Bone Related Proteins
Osteocalcin
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Mouse Proteins
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Mouse Zymogens
Factor X
Plasminogen
Prothrombin
Mouse Enzymes
Factor Xa
Plasmin
Other
Human Antithrombin III
Fibrinogen
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Other Species
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Rabbit
Thrombomodulin
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Inhibitors
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Other
Corn Trypsin Inhibitor (CTI)
DAPA
Human Protease Inhibitors
Human Antithrombin III
Heparin Cofactor II
TAFI
Angiostatin
Alpha-2-Plasmin Inhibitor
Chloromethylketones
Chloromethylketones
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Blood Collection Tubes
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Custom Collection Tubes
Custom Blood / Sample Collection Tubes
Corn Trypsin Inhibitor Tubes
Corn Trypsin Inhibitor Tubes
Activated Clotting Time Tubes
Activated Clotting Time Tubes
